Endocrine Abstracts

Macroprolactin is a high molecular weight IgG-prolactin complex which has reduced bioactivity. Macroprolactinaemia is a relatively common phenomenon, accounting for upto 20% of cases of hyperprolactinaemia in clinical practice; in the absence of amenorrhoea or hypogonadism these patients do not usually need dopamine agonist therapy. To ensure appropriate detection and management of such patients we routinely screen all serum samples with hyperprolactinaemia (>600 mU/l) for ...

Etomidate, an imidazole derived anaesthetic agent, potently inhibits adrenocortical 11-beta-hydroxylase at non-hypnotic doses in Cushing's syndrome. We report its use in controlling hypercortisolism in a patient with aggressive Cushing's disease requiring pelvic surgery for endometrial carcinoma.IJ, a 42-year old female was diagnosed with Cushing's disease in 1998 in Malaysia. 8am cortisol was 800nmol/l, midnight cortisol 659nmol/l and ACTH 103ng/l. MRI ...